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If both parents are carriers of a mutated gene for Usher syndrome, they will have a one-in-four chance of having a child with Usher syndrome with each birth. Individuals with a mutation in a gene that can cause an autosomal recessive disorder are called carriers, because they “carry” the gene with a mutation but show no symptoms of the disorder. If a child has a mutation in one Usher syndrome gene but the other gene is normal, he or she is predicted to have normal vision and hearing. The word recessive means that to have Usher syndrome, an individual must receive a mutated form of the Usher syndrome gene from each parent. The term autosomal means that the mutated gene is not located on either of the chromosomes that determine a person's sex in other words, both males and females can have the disorder and can pass along the disorder to a child. Usher syndrome is inherited as an autosomal recessive trait. Mutated genes may cause cells to act differently than expected. Each person inherits two copies of each gene, one from each parent. Genes contain instructions that tell cells what to do. Genes are located in almost every cell of the body. Usher syndrome is inherited, which means that it is passed from parents to their children through genes.
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